2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P5875
    P4pal10 1021346-05-3 98%
    P4pal10 is an antagonist for protease-activated receptor 4 (PAR4). P4pal10 inhibits the platelet aggregation, inhibits tissue factor (TF)-induced thrombin generation, and exhibits anticoagulant and antithrombotic activities. P4pal10 reduces the oedema and the granulocyte infiltration induced by Carrageenan (HY-125474). P4pal10 ameliorates the injury in mice myocardial ischemia/reperfusion (I/R) models.
    P4pal10
  • HY-P5889
    Thrombin receptor peptide ligand 287964-20-9 98%
    Thrombin receptor peptide ligand is a thrombin receptor antagonist peptide that can be used as an antithrombotic agent.
    Thrombin receptor peptide ligand
  • HY-P5891
    TAT-SAMβA 98%
    TAT-SAMβA is the peptide consist of RNAENFDRF (SAMβA; HY-P3429) conjugated to the cell penetrating TAT protein-derived peptide TAT47–57. TAT-SAMβA is a selective antagonist of Mfn1-βIIPKC association. TAT-SAMβA protects mouse embryonic fibroblast cells (MEFs) against oxidative stress-induced cytotoxicity.
    TAT-SAMβA
  • HY-P5908
    DEALA-Hyp-YIPD 98%
    DEALA-Hyp-YIPD is an HIF-1α peptide that inhibits VHL/HIF-1α interaction with an IC50 of 0.91 μM and a Kd of 180 nM.
    DEALA-Hyp-YIPD
  • HY-P5913
    [Tyr6]-Angiotensin II 52634-95-4 98%
    [Tyr6]-Angiotensin II is a peptide fragment , and can bind to the angiotensin converting enzyme 2 .
    [Tyr6]-Angiotensin II
  • HY-P5939
    Angiotensinogen (1-13) (human) 82048-97-3 98%
    Angiotensinogen (1-13) (human) is a fragment of the renin substrate angiotensinogen. Angiotensinogen is naturally occurring substrate for renin and a precursor for all angiotensin peptides.
    Angiotensinogen (1-13) (human)
  • HY-P5950
    ACTH (6-24) (human) 33512-65-1 98%
    ACTH (6-24) (human) (Adrenocorticotropic hormone (6-24)) is an ACTH fragment. ACTH (6-24) (human) is a competitive inhibitor of steroidogenesis induced by ACTH (1-39) and ACTH (5-24) (Kd:13.4 and 3.4 nM). ACTH (6-24) (human) inhibits corticosterone production and cAMP accumulation induced by hPTH 1-34.
    ACTH (6-24) (human)
  • HY-P5951
    Adrenomedullin (1-12) (human) 161206-81-1 98%
    Adrenomedullin (1-12) (human) is adrenomedullin fragment. Adrenomedullin has no effect on arterial pressure in cats
    Adrenomedullin (1-12) (human)
  • HY-P5978
    Atriopeptin III (rat) 90817-13-3 98%
    Atriopeptin III (ANP 127-150) (rat), a 24-amino acid atrial peptide, is a potent vasodilator and natriuretic/diuretic agent. Atriopeptin III (rat) improves renal functions and decreases blood pressure in a ureter-obstructed rat kidney model. Atriopeptin III (rat) can be used for research of chronic renal failure.
    Atriopeptin III (rat)
  • HY-P5991
    K-Casein (106-116),bovine 103951-35-5 98%
    K-Casein (106-116),bovine is a peptide that inhibits platelet aggregation and fibrinogen binding, plays an important role in atherosclerosis.
    K-Casein (106-116),bovine
  • HY-P6008
    Myoregulin 98%
    Myoregulin (MLN peptide) is a member of the regulin family. Myoregulin regulates muscle performance by modulating intracellular calcium handling. Myoregulin interactes directly with sarcoplasmic reticulum Ca2+-ATPase (SERCA) and impedinf Ca2+ uptake into the sarcoplasmic reticulum.
    Myoregulin
  • HY-P6023
    D-Leu-Pro-Arg-Rh110-D-Pro 98%
    D-Leu-Pro-Arg-Rh110-D-Pro is a substrate for Factor Xa I (FXIa) with binding affinity. D-Leu-Pro-Arg-Rh110-D-Pro consists of Rhodamine 110 (HY-D0817) linked to a peptide chain through a cleavable bond. Cleavable bond cleavage enhances fluorophore intensity. D-Leu-Pro-Arg-Rh110-D-Pro can be used to detect FXIa activity.
    D-Leu-Pro-Arg-Rh110-D-Pro
  • HY-P6437
    Drp1 peptide inhibitor P110 2770267-63-3 98%
    Drp1 peptide inhibitor P110 (Compound P110) is a selective Drp1 peptide inhibitor with neuroprotective properties. Drp1 peptide inhibitor P110 can inhibit the activation of Drp1, prevent MPTP-induced Drp1 mitochondrial translocation, and alleviate MPTP-induced dopaminergic neuron loss, dopaminergic nerve terminal damage, and behavioral deficits, and can be used in the study of Alzheimer's disease. Additionally, Drp1 peptide inhibitor P110 can reduce mitochondrial damage and organ injury in animal models of Huntington's disease, cerebral ischemic injury, and myocardial infarction.
    Drp1 peptide inhibitor P110
  • HY-Z0081
    2S,4R-Sacubitril 2307668-79-5 98%
    2S,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and agent Administration for use in combination with valsartan for the treatment of patients with heart failure.
    2S,4R-Sacubitril
  • HY-Z7082
    Perindopril L-arginine 612548-45-5 98%
    Perindopril L-arginine is an orally active and selective angiotensin-converting enzyme (ACE) inhibitor. Perindopril L-arginine reduces the production of angiotensin II by inhibiting ACE, thereby dilating blood vessels, lowering blood pressure, and also exerting activities such as vasculoprotection and antithrombosis. Perindopril L-arginine is promising for research of cardiovascular diseases.
    Perindopril L-arginine
  • HY-100141
    Ancarolol 75748-50-4 98%
    Ancarolol is a beta-adrenergic blocking agent.
    Ancarolol
  • HY-100151
    RGH-5526 69579-13-1 98%
    RGH-5526 (GYKI-11679) is a new antihypertensive agent.
    RGH-5526
  • HY-100160
    RP 54275 81364-78-5 98%
    RP 54275 (2-Octadecyl-1H-indole-5-carboxylic acid) is a novel hypocholesterolaemic agent.
    RP 54275
  • HY-100171
    PRX933 hydrochloride 639029-42-8 98%
    PRX933 hydrochloride is a 5-HT2c receptor agonist extracted from patent WO 2014140631 A1.
    PRX933 hydrochloride
  • HY-100194
    FKK 78299-79-3 98%
    FKK is an indazole derivative and also a novel bronchodilator.
    FKK
Cat. No. Product Name / Synonyms Application Reactivity